Gleevec Overview
What is Gleevec?
Gleevec (imatinib mesylate) is a prescription medicine used to treat certain types of cancer -- including Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). Gleevec works by preventing and stopping the growth of cancer cells.
CML is a disease in which the body makes too many abnormal white blood cells, making a person become sick more often, and feel weak and tired. Gleevec helps the body stop making these abnormal white blood cells.
GIST is a group of cancer cells that start growing in the wall of the stomach, intestines, or rectum. Gleevec also helps the body stop making these abnormal cells.
Gleevec is manufactured by Novartis Pharmaceuticals Corporation, and was approved by the U.S. Food and Drug Administration (FDA) in 2001.
Gleevec and the Risk of Heart Failure
Recent studies have suggested that Gleevec can cause heart problems for patients taking the drug to treat CML. In its August 2006 publication, Nature Medicine reported a study of ten CML patients who were treated with Gleevec and developed congestive heart failure after one to fourteen months.
On the other hand, studies have shown that Gleevec keeps between 80% and 90% of CML patients cancer free for at least five years. Because the overall survival rate of most CML patients treated with Gleevec is extremely high, and because the cancer relapse rate (as well as the number of reported heart failures) is low, many say that the benefits of Gleevec outweigh its risks.
Who Should Not Use Gleevec?
Women should avoid becoming pregnant while being treated with Gleevec.
Gleevec can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. To reduce the risk of infection or bleeding, you can take the following precautions:
- Avoid people with infections. Tell your healthcare professional immediately if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
- Check with your healthcare professional immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin.
- Be careful when using a regular toothbrush, dental floss, or toothpick. Talk to your healthcare professional about other ways you can clean your teeth and gums and before having any dental work done.
- Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
- Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
- Avoid contact sports or other situations where bruising or injury could occur.
Page 1 of 3
Next Page
Most content above from the U.S. Food and Drug Administration and the U.S. National Library of Medicine and the National Institutes of Health
