What is Fosamax?

Fosamax (alendronate sodium) is a prescription medicine used to prevent or treat osteoporosis in women after menopause, and to treat osteoporosis in men. Osteoporosis is a medical condition in which the bones become thin and weak and break easily. Osteoporosis may have natural causes or may be found in men and women who have taken corticosteroids.

Fosamax can also be used to treat Paget's disease, a medical condition in which the body replaces healthy bones with weak bones.

Fosamax works by preventing bone breakdown and increasing bone density (thickness) in order to make bone stronger and less likely to break.

Fosamax is a bisphosphonate drug made by Merck and Company, Inc., and was approved by the U.S. Food and Drug Administration (FDA) in 1999.

Fosamax and Osteonecrosis of the Jaw

There have been recent reports linking Fosamax to a serious side effect called Osteonecrosis of the Jaw (ONJ) or 'jaw death.' ONJ is a medical condition in which the jawbone partially crumbles and dies. ONJ may cause severe pain, loose teeth, exposed bone, loss of function, and disfigurement.

Fosamax maker Merck and Company, Inc., has stated that ONJ is a rare side effect, and that in controlled clinical trials involving more than 17,000 patients, there were no reports of ONJ.

Most researchers and doctors interviewed in recent news reports appear to believe that the benefits of bisphosphonate drugs greatly outweigh the risks, and say that they will continue prescribing these medicines to their patients. In the past, it appears that most reported instances of ONJ have been with cancer patients taking bisphosphonate medications intravenously.

Taking Fosamax

Take Fosamax orally with a full glass (6 to 8 oz.) of plain water on an empty stomach. Fosamax should be taken in the morning, at least 30 minutes before taking any food, beverage, or other medicines (such as antacids or calcium and vitamin supplements). Taking other food and beverages within 30 minutes of taking Fosamax will decrease the amount of absorption by the body.

Do not lie down for 30 minutes after taking Fosamax. Remaining upright prevents irritation to the esophagus and allows Fosamax to reach your stomach faster.

When taking Fosamax, follow your healthcare professional's orders or the directions on the label. If your dose is different than what is on the label, do not change it unless instructed by your healthcare professional. If you miss a dose of Fosamax, do not take it later in the day. Simply resume your usual schedule the next morning. Do not double dose.