What is Effexor?
Effexor (venlafaxine) is used to treat depression. Effexor XR (venlafaxine hydrochloride; extended release capsules) is used to treat depression, generalized anxiety disorder (GAD), and social anxiety disorder (SAD). Effexor is made by Wyeth Pharmaceuticals, Inc. and was approved by the U.S. Food and Drug Administration (FDA) in 1993.
Taking Effexor
Effexor is taken by mouth, with food, as prescribed by your healthcare professional. Swallow capsules whole, without crushing or chewing. You may, however, open the capsule, sprinkle contents on a spoonful of applesauce, take right away without chewing, and follow with a glass of water.
Effexor FDA Alert
In July 2006, the FDA issued an alert stating that a life-threatening condition called serotonin syndrome can occur when medicines called Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs, such as Effexor) and medicines used to treat migraine headaches known as 5-hydroxytryptamine receptor agonists (triptans), are taken together. Signs and symptoms of serotonin syndrome include:
- restlessness
- hallucinations
- loss of coordination
- fast heartbeat
- increased body temperature
- fast changes in blood pressure
- overactive reflexes
- diarrhea
- coma
- nausea
- vomiting
Serotonin syndrome may be more likely to occur when starting or increasing the dose of an SNRI or a triptan. If you take migraine headache medicines, ask your healthcare professional if your medicine is a triptan.
More information on antidepressants is available from the FDA here.
Effexor and Increased Risk of Suicidality
In October 2004, the FDA issued a public health advisory directing all antidepressant drug manufacturers to revise their products' labeling to include boxed warning and expanded warning statements that alert healthcare providers to an increased risk of suicidality (suicidal thinking and behavior) in children and adolescents being treated with these medications. Effexor maker Wyeth Pharmaceuticals, Inc. has since added a black box warning to Effexor prescribing information in response to the FDA advisory. Click here for more information on this advisory.
In June 2005, the FDA announced that several recent scientific publications suggested the possibility of an increased risk for suicidal behavior in adults being treated with antidepressant medications, including Effexor. The FDA advised that adults taking antidepressants, particularly those being treated for depression, should be watched closely for worsening depression and increased suicidality. Monitoring these patients is especially important when treatment begins, and when doses are increased or decreased. The FDA is working closely with antidepressant manufacturers to fully evaluate the risk of suicidality in adults treated with these medications. Click here for more information on this advisory.
Who Should Not Take Effexor?
Never take Effexor if you are taking another drug used to treat depression called a Monoamine Oxidase Inhibitor (MAOI), or if you have stopped taking an MAOI in the last 14 days. Taking Effexor and an MAOI within a close period of time can result in serious (and sometimes fatal) reactions including:
- High body temperature
- Coma
- Seizures (convulsions)
MAOI drugs include:
- Nardil (phenelzine sulfate)
- Parnate (tranylcypromine sulfate)
- Marplan (isocarboxazid)
- Other brands
